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KMID : 0350519940470041651
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Journal of Catholic Medical College
1994 Volume.47 No. 4 p.1651 ~ p.1664
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A Study on Estrogen and Progesterone Receptor Expression in Neuroepithelial Tumors
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Abstract
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There exist many controversial debates on the presence of estrogen and progesterone receptor in neuroepithelial tumors. The receptors of two female sex steroid hormone, estrogen and progesterone, were examined in 24 neuroepithelial tumors. Using
a
dextran-coated chacoal(DCC) assay, high affinity binding sites were found in the cytosolic fraction with the mean capacity of 3.42±4.56 and 4.71±5.54 fmol/mg cytosol protein, respectively. None of the tumors were stained positively for estrogen
receptors and only 2 cases were stained positively ofr progesterone receptors with immunohistochemical technique. In addition, convincing evidence for the absence of estrogen and progesterone receptors was obtained by reverse transcription
polymerase
chain reaction (RT-PCR) and Southern blot hybridization using oligonucleotide probes which are complementary to the fragments of the human estrogen and progesterone receptors' messenger ribonucleic acid (mRNA). Out of 24 neuroepithelial tumors,
we
were
not alble to find any expression of mRNAs coding for the estrogen and progesterone receptors.
From the present study it is concluded that estrogen and progesterone receptors are essentially absent in neuroepithelial tumors. This study suggests that estrogen and progesterone receptors are not involved in neuroepithelial tumors, having no
current
significance as markers for adjuvant medical therapy of most neuroepithelial tumors.
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KEYWORD
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